Stermitz Group
Frank R. Stermitz

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RESEARCH SUMMARY - FRANK R. STERMITZ

Antibiotic resistance is an insidious and growing problem. Every newly discovered antibiotic (natural or synthetic) seems destined to become ineffective as pathogenic microbes become resistant to these substances. We are engaged in finding compounds from natural sources which have no antibiotic activity themselves, but which overcome the resistance bacteria have developed. By attacking the reason for resistance, we hope to obtain compounds which will be useful adjuncts to known antibacterials.

F. R. Stermitz, P. Lorenz, J. N. Tawara, L. A. Zenewicz, and K. Lewis (2000). Synergy in a medicinal plant: Antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Proc. Natl. Acad. Sci. U.S. A. 97:1433-1437

N. R. Guz and F. R. Stermitz (2000). Synthesis and structures of regioisomeric hydnocarpin-type flavonolignans. J. Nat. Prod. 63:1140-1145.

Zenewicz, and K. Lewis (2000). 5'-Methoxyhydnocarpin-D and pheophorbide aBerberis species components that potentiate berberine growth inhibition of resistant Staphylococcus aureus. J. Nat. Prod. 63: 1146-1149.

N. R. Guz, F. R. Stermitz, J. B. Johnson, T. D. Beeson, S. Willen, J.-H. Hsiang, and K. Lewis (2001). Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships. J. Med. Chem. 44:261-268.

F. R. Stermitz, T. D. Beeson, P. J. Mueller, J.-F. Hsiang, and K. Lewis (2001). Staphylococcus aureus MDR efflux pump inhibitors from a Berberis and a Mahonia (sensu strictu) species. Biochem. Syst. Ecol. 29:793-798.

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